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KMID : 0363020090390000269
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Journal of Korean Academy of Periodontology
2009 Volume.39 No. 0 p.269 ~ p.278
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MMP-1 promoter polymorphism in Korean with generalized aggressive periodontitis
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Oh Hyong-Suk
Chung Hyun-Ju
Kim Ok-Su
Kim Young-Joon
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Abstract
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Purpose: The aim of this study was to investigate matrix metalloproteinase 1 (MMP-1) gene polymorphism (1G/2G at -1607 and A/G at -519) in Korean subject and to assess the association between polymorphism and periodontal status.
Methods: Forty nine generalized aggressive periodontitis (GAP) patients and 57 periodontally healthy children were recruited and genomic DNA was extracted from buccal swab. The polymorphisms of MMP-1 promoter genes were determined by polymerase chain reaction and restriction fragment length product (PCR-RFLP) method. The distribution of genotype and allele frequency was compared between 2 groups by χ2 test.
Results: There was a significant difference in the distribution of genotypes and frequency of alleles between the GAP and reference groups at the position -519 of MMP-1 gene promoter (P < 0.05). Allele G carrier rate was significantly lower in GAP group than that of the reference group (P < 0.001). At the position -1607 of MMP-1 gene promoter, genotype distribution and allele frequency showed no statistically significant difference between the groups. However, in the female group, a significant difference was observed between the groups for the genotype distribution, allele frequency and allele 1G carrier rate (P < 0.05).
Conclusions: The DNA polymorphism at the MMP-1 gene promoter might be associated with GAP in Korean.
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KEYWORD
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aggressive periodontitis, genetic polymorphism, matrix metalloproteinase 1
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